Size:100 ul
$319.00
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SKU
ARP57977_P050
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Conjugation Options

ARP57977_P050-FITC Conjugated

ARP57977_P050-HRP Conjugated

ARP57977_P050-Biotin Conjugated

ATF5 Antibody - middle region (ARP57977_P050)

Catalog#: ARP57977_P050
Domestic: within 1-2 days delivery International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-377168 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human ATF5
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
Complete computational species homology data Anti-ATF5 (ARP57977_P050)
Peptide Sequence Synthetic peptide located within the following region: LPPPQQPPPPSPPQPSRLAPYPHPATTRGDRKQKKRDQNKSAALRYRQRK
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-ATF5 (ARP57977_P050) antibody is Catalog # AAP57977 (Previous Catalog # AAPP32388)
Datasheets/Manuals Printable datasheet for anti-ATF5 (ARP57977_P050) antibody
Target Reference Zhou,D., (2008) J. Biol. Chem. 283 (11), 7064-7073
Publications

Wei, Y. et al. Cdc34-mediated degradation of ATF5 is blocked by cisplatin. J. Biol. Chem. 283, 18773-81 (2008). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish 18458088

Gene Symbol ATF5
Official Gene Full Name Activating transcription factor 5
Alias Symbols ATFX, FLJ34666, HMFN0395
NCBI Gene Id 22809
Protein Name Cyclic AMP-dependent transcription factor ATF-5
Description of Target ATF5 belongs to the bZIP family. It is transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Loss of ATF5 is associated with hepatocellular carcinoma.
Swissprot Id B3KND3
Protein Accession # NP_036200
Nucleotide Accession # NM_012068
Protein Size (# AA) 282
Molecular Weight 31kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ATF5.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ATF5.
Protein Interactions CEBPE; CEBPA; GIT2; ATXN1; EP300; CCND3; GABBR2; DISC1; GABBR1; CEBPG; CDC34; TRIB3; UBC; CD34;
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