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Catalog No: OPCD01525
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OPCD01525
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Datasheets/ManualsPrintable datasheet for ATF4 Recombinant Protein (OPCD01525)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Val126-Thr291
::Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Cytoskeleton, microtubule organizing center, centrosome
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolAtf4
Gene Full Nameactivating transcription factor 4
Alias SymbolsActivating transcription factor 4;Atf-;Atf-4;C/AT;C/ATF;c/EBP-related ATF;cAMP-dependent transcription factor ATF-4;cAMP-responsive element-binding protein 2;CREB;CREB2;CREB-2;cyclic AMP-dependent transcription factor ATF-4;cyclic AMP-responsive element-binding protein 2;TAXREB;TAXREB67;taxREB67 homolog;tax-responsive enhancer element-binding protein 67 homolog.
NCBI Gene Id11911
Protein NameCyclic AMP-dependent transcription factor ATF-4
Description of TargetTranscriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
Uniprot IDQ06507
Protein Accession #NP_001274109.1
Nucleotide Accession #NM_001287180.1
Protein Size (# AA)Val126~Thr291
Molecular Weight22kDa
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