Catalog No: OPCD01525
Price: $0.00
SKU
OPCD01525
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Datasheets/Manuals | Printable datasheet for ATF4 Recombinant Protein (OPCD01525) |
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Predicted Species Reactivity | Mouse|Mus musculus |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
:: | Residues: Val126-Thr291 |
:: | Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Cytoskeleton, microtubule organizing center, centrosome |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 95% |
Source | E.coli |
Tag | N-terminal His Tag |
Gene Symbol | Atf4 |
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Gene Full Name | activating transcription factor 4 |
Alias Symbols | Activating transcription factor 4;Atf-;Atf-4;C/AT;C/ATF;c/EBP-related ATF;cAMP-dependent transcription factor ATF-4;cAMP-responsive element-binding protein 2;CREB;CREB2;CREB-2;cyclic AMP-dependent transcription factor ATF-4;cyclic AMP-responsive element-binding protein 2;TAXREB;TAXREB67;taxREB67 homolog;tax-responsive enhancer element-binding protein 67 homolog. |
NCBI Gene Id | 11911 |
Protein Name | Cyclic AMP-dependent transcription factor ATF-4 |
Description of Target | Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. |
Uniprot ID | Q06507 |
Protein Accession # | NP_001274109.1 |
Nucleotide Accession # | NM_001287180.1 |
Protein Size (# AA) | Val126~Thr291 |
Molecular Weight | 22kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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