ATF4 Recombinant Protein (OPCD01524)

Catalog No: OPCD01524

ATF4 Recombinant Protein (OPCD01524) using SDS-PAGE

ATF4 Recombinant Protein (OPCD01524) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Val125-Tyr329
  Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Cytoskeleton, microtubule organizing center, centrosome
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Atf4
• Gene Full Name: activating transcription factor 4
• Alias Symbols: Activating transcription factor 4;activating transcription factor 4 (tax-responsive enhancer element B67);activating transcription factor ATF-4;cAMP-dependent transcription factor ATF-4;cyclic AMP-dependent transcription factor ATF-4;rATF-4.
• NCBI Gene Id: 79255
• Protein Name: Cyclic AMP-dependent transcription factor ATF-4
• Description of Target: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity).
• Uniprot ID: Q9ES19
• Protein Accession #: NP_077379.1
• Nucleotide Accession #: NM_024403.2
• Protein Size (# AA): Val125~Tyr329
• Molecular Weight: 26kDa