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ATF4 Antibody (OAAB21714)

100 ul
$390.00
In Stock
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB, IF, IHC-P
Additional Information:
Function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
ATF4
Official Gene Full Name:
activating transcription factor 4
NCBI Gene Id:
468
Swissprot Id:
P18848
Protein Accession #:
NP_001666.2
Nucleotide Accession #:
NM_001675.4
Alias Symbols:
CREB2, TXREB, CREB-2, TAXREB67
Replacement Item:
This antibody may replace item sc-200 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
Molecular Weight:
39 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ATF4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ATF4.
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Datasheets/Manuals:
Printable datasheet for anti-ATF4 (OAAB21714) antibody
Preservative:
0.03% Proclin300 and 50% glycerol
Formulation:
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Application Info:
WB: 1:100~1:500
IHC-P: 1:100~1:500

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