Catalog No: OAAF00967 (Formerly GWB-ASC375)
Size:100 ug
Price: $344.00
SKU
OAAF00967
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for ATF2 Antibody (OAAF00967)
Product Info
Predicted Species ReactivityHuman|Rat
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationEnzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human ATF2.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
SpecificityATF2 antibody detects endogenous levels of total ATF2 protein.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
Application InfoIHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:1000
ReferenceMaekawa T., EMBO J. 8:2023-2028(1989).
Yang L., J. Immunol. 158:2522-2525(1997).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004)
Gene SymbolATF2
Gene Full Nameactivating transcription factor 2
Alias SymbolsActivating transcription factor 2;activating transcription factor 2 splice variant ATF2-var2;cAMP response element-binding protein CRE-BP1;cAMP responsive element binding protein 2, formerly;cAMP-dependent transcription factor ATF-2;CREB2;CREB-2;CRE-BP1;cyclic AMP-dependent transcription factor ATF-2;cyclic AMP-responsive element-binding protein 2;HB16;histone acetyltransferase ATF2;TREB7.
NCBI Gene Id1386
Protein NameCyclic AMP-dependent transcription factor ATF-2
Description of TargetTranscriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Uniprot IDP15336
Protein Accession #NP_001243019.1
Molecular Weight52 kDa
  1. What is the species homology for "ATF2 Antibody (OAAF00967)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Rat".

  2. How long will it take to receive "ATF2 Antibody (OAAF00967)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "ATF2 Antibody (OAAF00967)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ATF2 Antibody (OAAF00967)"?

    This target may also be called "Activating transcription factor 2;activating transcription factor 2 splice variant ATF2-var2;cAMP response element-binding protein CRE-BP1;cAMP responsive element binding protein 2, formerly;cAMP-dependent transcription factor ATF-2;CREB2;CREB-2;CRE-BP1;cyclic AMP-dependent transcription factor ATF-2;cyclic AMP-responsive element-binding protein 2;HB16;histone acetyltransferase ATF2;TREB7." in publications.

  5. What is the shipping cost for "ATF2 Antibody (OAAF00967)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ATF2 Antibody (OAAF00967)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ATF2 Antibody (OAAF00967)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "52 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ATF2 Antibody (OAAF00967)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ATF2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ATF2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ATF2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ATF2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ATF2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ATF2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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