ASPN Recombinant Protein (OPCD01506)

Catalog No: OPCD01506

ASPN Recombinant Protein (OPCD01506) using SDS-PAGE

ASPN Recombinant Protein (OPCD01506) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Lys16-Lys373
  Subcellular Location: Secreted, Extracellular matrix
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Aspn
• Gene Full Name: asporin
• Alias Symbols: 4631401G09Rik;AA986886;asporin;periodontal ligament-associated protein 1;PL;Plap1;SL;Slrr1c.
• NCBI Gene Id: 66695
• Protein Name: Asporin
• Description of Target: Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro.
• Uniprot ID: Q99MQ4
• Protein Accession #: NP_001165952.1
• Nucleotide Accession #: NM_001172481.1
• Protein Size (# AA): Lys16~Lys373
• Molecular Weight: 71kDa