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ASGR2 Antibody - N-terminal region (ARP33820_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP33820_P050-FITC Conjugated

ARP33820_P050-HRP Conjugated

ARP33820_P050-Biotin Conjugated

Gene Symbol:
ASGR2
Official Gene Full Name:
asialoglycoprotein receptor 2
NCBI Gene Id:
433
Protein Name:
Asialoglycoprotein receptor 2
Swissprot Id:
P07307
Protein Accession #:
NP_001172
Nucleotide Accession #:
NM_001181
Alias Symbols:
HL-2, HBXBP, ASGPR2, ASGP-R2, CLEC4H2
Replacement Item:
This antibody may replace item sc-13471, HPA015998
Description of Target:
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein Size (# AA):
311
Molecular Weight:
35kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ASGR2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ASGR2.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human ASGR2
Predicted Species Reactivity:
Human, Pig, Rat, Yeast
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human: 100%; Pig: 77%; Rat: 79%; Yeast: 77%
Complete computational species homology data:
Anti-ASGR2 (ARP33820_P050)
Peptide Sequence:
Synthetic peptide located within the following region: LVVICVTGSQSEGHRGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGS
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
HDAC3; UBC; CDK6; CDK4; COPS5; TADA3; CDKN2A;
Blocking Peptide:
For anti-ASGR2 (ARP33820_P050) antibody is Catalog # AAP33820 (Previous Catalog # AAPP04886)
Datasheets/Manuals:
Printable datasheet for anti-ASGR2 (ARP33820_P050) antibody
Target Reference:
Yik,J.H., et al., (2002) J. Biol. Chem. 277 (43), 40844-40852
Publications:

Chang, T.-C. et al. Synthesis and evaluation of a photoactive probe with a multivalent carbohydrate for capturing carbohydrate-lectin interactions. Bioconjug. Chem. 24, 1895-906 (2013). IHC, WB, Human, Pig, Rat, Yeast 24151840

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