Ascomycin (OOMC00027)

Catalog No: OOMC00027

Product Info

• Product Format: Powder
• Additional Information: CAS: 104987-12-4
  Molecular Formula: C43H69NO12
  Chemical Name: Fermentation product from Streptomyces hygroscopicus
  Primary Activity: FKBP ligand
  COVID-19 Rationale: mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins
• Reconstitution and Storage: Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming). Store at -20C.
• Purity: > 98%
• Reference: 1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosupressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729

Target Info

• Alias Symbols: FK-520, FR-900520
• Molecular Weight: 729.03 g/mol