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ASCL1 antibody - N-terminal region (ARP32355_T100)

100 ul
$249.00
In Stock
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Conjugation Options

ARP32355_T100-FITC Conjugated

ARP32355_T100-HRP Conjugated

ARP32355_T100-Biotin Conjugated

Gene Symbol:
ASCL1
NCBI Gene Id:
429
Official Gene Full Name:
Achaete-scute complex homolog 1 (Drosophila)
Protein Name:
Achaete-scute homolog 1
Swissprot Id:
P50553
Protein Accession #:
NP_004307
Nucleotide Accession #:
NM_004316
Alias Symbols:
ASH1, HASH1, MASH1, bHLHa46
Replacement Item:
This antibody may replace item sc-13219 from Santa Cruz Biotechnology.
Description of Target:
ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers.
Protein Size (# AA):
236
Molecular Weight:
25kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ASCL1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ASCL1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human ASCL1
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 92%; Guinea Pig: 100%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%
Complete computational species homology data:
Anti-ASCL1 (ARP32355_T100)
Peptide Sequence:
Synthetic peptide located within the following region: QSAQQQQQQQQQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELM
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
MEF2D; MEF2C; MEF2A; NEUROG2; UBQLN1; EP300; TCF4; BMP2; ASCL1;
Blocking Peptide:
For anti-ASCL1 (ARP32355_T100) antibody is Catalog # AAP32355 (Previous Catalog # AAPP03344)
Datasheets/Manuals:
Printable datasheet for anti-ASCL1 (ARP32355_T100) antibody
Target Reference:
Somasundaram,K., et al., (2005) Oncogene. 24(47), 7073-83
Publications:

Vias, M. et al. Pro-neural transcription factors as cancer markers. BMC Med. Genomics 1, 17 (2008). IHC, WB, Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat 18489756

Suozzi, A., Malatesta, M. & Zancanaro, C. Subcellular distribution of key enzymes of lipid metabolism during the euthermia-hibernation-arousal cycle. J. Anat. 214, 956-62 (2009). IHC, WB, Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat 19538638

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