ARHGEF7 Antibody - middle region (OASG05888)

Catalog No: OASG05888

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human PIXBeta. Location: 280-360aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: PIXBeta Polyclonal Antibody detects endogenous levels of PIXBeta protein.
• Application Info: WB 1:500~2000
  IHC 1:100~300
  ELISA 1:5000
  
• Publications:

  Platelet-derived growth factor receptor-a and Ras-related C3 botulinum toxin substrate-1 regulate mechano-responsiveness of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 313, L1174-L1187 (2017). 28775097

Target Info

• Gene Symbol: ARHGEF7
• Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 7
• Alias Symbols: P50, P85, PAK3, PIXB, COOL1, P50BP, COOL-1, P85SPR, BETA-PIX, P85COOL1, Nbla10314
• NCBI Gene Id: 8874; 54126; 114559
• Description of Target: Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Uniprot ID: Q14155, Q9ES28, O55043
• Molecular Weight: 75/80 kDa