ARHGAP17 Antibody (OAAF04182)

Catalog No: OAAF04182 (Formerly GWB-ASE946)

Size:100 ug

Western blot analysis of extracts from LOVO cells, using RHG17 Antibody. The lane on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human RHG17.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: RHG17 antibody detects endogenous levels of total RHG17 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; ELISA: 1:40000
• Reference: Richnau N., J. Biol. Chem. 276:35060-35070(2001).
  Ota T., Nat. Genet. 36:40-45(2004).
  The German cDNA consortium; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.

Target Info

• Gene Symbol: ARHGAP17
• Gene Full Name: Rho GTPase activating protein 17
• Alias Symbols: MST066;MST110;MSTP038;MSTP066;MSTP110;NADRIN;neuron-associated developmentally regulated protein;PP367;PP4534;rho GTPase-activating protein 17;RhoGAP interacting with CIP4 homologs 1;RhoGAP interacting with CIP4 homologs protein 1;rho-type GTPase-activating protein 17;RICH1;RICH-1;WBP15.
• NCBI Gene Id: 55114
• Protein Name: Rho GTPase-activating protein 17
• Description of Target: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
• Uniprot ID: Q68EM7
• Protein Accession #: NP_001006635.1
• Molecular Weight: 95 kDa