ARG2 Recombinant Protein (OPCD01476)

Catalog No: OPCD01476

ARG2 Recombinant Protein (OPCD01476) using SDS-PAGE

ARG2 Recombinant Protein (OPCD01476) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Val23-Ile354
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Arg2
• Gene Full Name: arginase type II
• Alias Symbols: AII;arginase II;arginase-2, mitochondrial;AU022422;kidney-type arginase;non-hepatic arginase;type II arginase.
• NCBI Gene Id: 11847
• Protein Name: Arginase-2, mitochondrial
• Description of Target: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970, PubMed:25009204). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (PubMed:27074721). May play a role in promoting prenatal immune suppression (By similarity). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (By similarity).
• Uniprot ID: O08691
• Protein Accession #: NP_033835.1
• Nucleotide Accession #: NM_009705.3
• Protein Size (# AA): Val23~Ile354
• Molecular Weight: 66kDa