AQP3 Antibody - middle region (OAAB14863)

Catalog No: OAAB14863

Size:400ul

AQP3 Antibody (Center) (Cat. # OAAB14863) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).

AQP3 Antibody (Center) (Cat. # OAAB14863) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
• Additional Information: Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity)
  Cellular Location: Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney
  Tissue Location: Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level
  
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This AQP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human AQP3.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Cow; Human; Mouse; Rat
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Intended Use: AQP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: AQP3
• Alias Symbols: GIL, AQP-3
• NCBI Gene Id: 360
• Protein Name: Aquaporin-3
• Description of Target: Aquaporin 3 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms.
• Uniprot ID: Q92482
• Protein Accession #: NP_004916.1
• Molecular Weight: 31544 Da