APTX Protein (OPPA01800)

Catalog No: OPPA01800 (Formerly GWB-7ADE0F)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The APTX solution contains 20mM Tris-HCl pH-7.5, 0.1M NaCl, 0.1mM PMSF and 20% glycerol. Physical appearance: Sterile Filtered clear colorless solution.
• Host: E. Coli
  Product Introduction: APTX is a DNA-binding protein which participates in single-strand DNA break repair, double-strand DNA break repair and base excision repair. APTX determines abortive DNA ligation intermediates created each at base excision sites, or while DNA ligases attempt to restore non-ligatable breaks induced by reactive oxygen species. APTX catalyzes the release of adenylate groups covalently linked to 5''-phosphate termini, resulting in the production of 5''-phosphate termini that can be efficiently rejoined. APTX hydrolyzes adenosine 5''-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.
  Product Description: APTX Human Recombinant fused to 37 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 205 amino acids (1-168 a.a.) and having a molecular mass of 23.9 kDa. The APTX is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: APTX Recombinant Human although stable at 4C for 30 days, should be stored desiccated below -20C for periods greater than 30 days. Please avoid freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWAGSMQD PKMQVYKDEQ VVVIKDKYPK ARYHWLVLPW TSISSLKAVA REHLELLKHM HTVGEKVIVD FAGSSKLRFR LGYHAIPSMS HVHLHVISQD FDSPCLKNKK HWNSFNTEYF LESQAVIEMV QEAGRVTVRD GMPELLKLPL RCHECQQLLP SIPQLKEHLR KHWTQ.

Target Info

• Gene Symbol: APTX
• Alias Symbols: AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT
• NCBI Gene Id: 54840
• Protein Name: Aprataxin
• Description of Target: Recombinant Human Aprataxin
• Uniprot ID: Q7Z2E3
• Protein Accession #: NP_060162.1
• Protein Size (# AA): Recombinant