APOOL Antibody (OAAF03292)

Catalog No: OAAF03292 (Formerly GWB-ASE361)

Size:100 ug

Western blot analysis of extracts from COLO/NIH-3T3 cells, using APOOL Antibody. The lane on the right is blocked with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human APOOL.
• Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
• Concentration: 1 mg/ml
• Specificity: APOOL antibody detects endogenous levels of total APOOL protein.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB 1:500~1000
  ELISA 1:40000
  
• Reference: Clark H.F., Genome Res. 13:2265-2270(2003).
  Ross M.T., Nature 434:325-337(2005).
  The MGC Project Team; Genome Res. 14:2121-2127(2004).
• Publications:

  Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv. 3, e1700677 (2017). 28835921

  QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Elife. 4, (2015). 25997101

  QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease. Elife. 5, (2016). 27623147

• Description:
  View product citations for APOOL Antibody (OAAF03292) on CiteAb

Target Info

• Gene Symbol: APOOL
• Gene Full Name: apolipoprotein O like
• Alias Symbols: AAIR8193;Apolipoprotein O-like;CXorf33;FAM121A;family with sequence similarity 121A;Mic27;MICOS complex subunit MIC27;MICOS27;mitochondrial contact site and cristae organizing system subunit 27;Protein FAM121A;UNQ8193.
• NCBI Gene Id: 139322
• Protein Name: MICOS complex subunit MIC27
• Description of Target: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).
• Uniprot ID: Q6UXV4
• Protein Accession #: NP_940852.3
• Molecular Weight: 29 kDa