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Catalog No: OASA11404 (Formerly GWB-Q00976)
Size:100UG
Price: $459.00
SKU
OASA11404
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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APOLIPOPROTEIN E Antibody (OASA11404)

Datasheets/ManualsPrintable datasheet for APOLIPOPROTEIN E Antibody (OASA11404)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. Phosphate buffered saline
ClonalityMonoclonal
IsotypeIgG1
HostMouse
ApplicationELISA, WB
Additional InformationPreparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Preservative Stabilisers: 0.09% Sodium Azide (NaN3)
::Buffer Solutions: Phosphate buffered saline
Reconstitution and Storage-20°C
ImmunogenPurified ApoHDL fraction.
PurificationProtein G Purified
Predicted Homology Based on Immunogen SequenceHuman
Concentration1 mg/ml
SpecificityOASA11404 specifically recognises an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents.
Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB,E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype.
Clone WUE-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB,E cell receptor, see Krul, E.S et al for details. Aviva recommends the use of OASA11403 for functional studies.
Application InfoWestern Blotting: OASA11404 detects a major band of approximately 34-36kDa in human liver cell lysates.
ELISA: 1/100 - 1/1000
Alias SymbolsAD2, LPG, APO-E, ApoE4, LDLCQ5
NCBI Gene Id348
Protein NameApolipoprotein E
Uniprot IDP02649
Protein Accession #NP_000032.1
  1. What is the species homology for "APOLIPOPROTEIN E Antibody (OASA11404)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "APOLIPOPROTEIN E Antibody (OASA11404)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "APOLIPOPROTEIN E Antibody (OASA11404)" provided in?

    This item is provided in "Liquid. Phosphate buffered saline".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "APOLIPOPROTEIN E Antibody (OASA11404)"?

    This target may also be called "AD2, LPG, APO-E, ApoE4, LDLCQ5" in publications.

  5. What is the shipping cost for "APOLIPOPROTEIN E Antibody (OASA11404)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "APOLIPOPROTEIN E Antibody (OASA11404)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "APOLIPOPROTEIN E Antibody (OASA11404)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "APOLIPOPROTEIN E Antibody (OASA11404)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for ""?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for ""?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with ""?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with ""?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with ""?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with ""?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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