Catalog No: OPCA03165
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APOBEC3A Recombinant Protein (Human) (OPCA03165)

Datasheets/ManualsPrintable datasheet for APOBEC3A Recombinant Protein (Human) (OPCA03165)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid or Lyophilized powder
Reconstitution and StorageWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
PurificationAffinity purified using IMAC
PurityGreater than 90% as determined by SDS-PAGE.
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
SourceE. Coli
Protein Range1-199 aa
TagN-terminal 6xHis-SUMO-tagged
ReferencePsoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.Madsen P.P., Anant S., Rasmussen H.H., Gromov P., Vorum H., Dumanski J.P., Tommerup N., Collins J.E., Wright C.L., Dunham I., Macginnitie A.J., Davidson N.O., Celis J.E.J. Invest. Dermatol. 113:162-169(1999)
Gene SymbolAPOBEC3A
Alias SymbolsPhorbolin-1
NCBI Gene Id100913187
Protein Nameprobable DNA dC->dU-editing enzyme APOBEC-3A
Description of TargetDNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Uniprot IDP31941
Protein Accession #NP_001180218.1
Nucleotide Accession #NM_001193289.1
Protein Size (# AA)1-199 aa
Molecular Weight39 kDa
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