Catalog No: OPCA03165
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APOBEC3A Recombinant Protein (Human) (OPCA03165)

Datasheets/ManualsPrintable datasheet for APOBEC3A Recombinant Protein (Human) (OPCA03165) (OPCA03165)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatLyophilized 20mM Tris-HCl, 0.5M NaCl, 6% Trehalose (pH 8.0)
Reconstitution and StorageWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
PurificationAffinity purified using IMAC
PurityGreater than 90% as determined by SDS-PAGE.
Protein Range1-199 aa
TagN-terminal 6xHis-SUMO-tagged
ReferencePsoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.Madsen P.P., Anant S., Rasmussen H.H., Gromov P., Vorum H., Dumanski J.P., Tommerup N., Collins J.E., Wright C.L., Dunham I., Macginnitie A.J., Davidson N.O., Celis J.E.J. Invest. Dermatol. 113:162-169(1999)
Gene Full NameAPOBEC3A and APOBEC3B deletion hybrid|apolipoprotein B mRNA editing enzyme catalytic subunit 3A
Alias SymbolsA3A;APOBEC3A;apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A;ARP3;bK150C2.1;DNA dC->dU-editing enzyme APOBEC-3A;phorbolin-1;PHRBN;probable DNA dC->dU-editing enzyme APOBEC-3A.
NCBI Gene Id100913187|200315
Protein NameDNA dC->dU-editing enzyme APOBEC-3A
Description of TargetDNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Uniprot IDP31941
Protein Accession #NP_001180218.1
Nucleotide Accession #NM_001193289.1
Protein Size (# AA)Recombinant
Molecular Weight39 kDa
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