APLP2 Antibody - middle region (ARP73748_P050)

Catalog No: ARP73748_P050

Host: Rabbit
Target Name: APLP2
Sample Type: ACHN Whole Cell lysates
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human APLP2
• Purification: Affinity Purified
• Peptide Sequence: Synthetic peptide located within the following region: DEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-APLP2 (ARP73748_P050) antibody is Catalog # AAP73748

Target Info

• Gene Symbol: APLP2
• Alias Symbols: APPH, APPL2, CDEBP, APLP-2
• NCBI Gene Id: 334
• Description of Target: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Uniprot ID: Q06481-6
• Protein Size (# AA): 761
• Molecular Weight: 83kDa
• Protein Interactions: UBC; SUMO2; ETS1; JUNB; JUN; DEDD; MAPK8; RPL26; ZNF512B; VKORC1; ADIPOR1; KAT5; BAG6; ELAVL1; HDAC5; RYK; DAB1; APBB3; APBB2; APBB1; PRKCA; PRNP; PIK3CA; AKT1; HLA-A; CDK1; APLP2; HGS; DAB2; SFN; BRCA1;