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Catalog No: OAAB19606
Size:100ul
Price: $438.00
SKU
OAAB19606
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for anti-APEX1 (OAAB19606) antibody
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product Format0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
ClonalityPolyclonal
HostRabbit
ApplicationWB, IHC-P
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Application InfoWB: 1:1000
ReferenceRobson C.N.,et al.Nucleic Acids Res. 19:5519-5523(1991).
Demple B.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:11450-11454(1991).
Seki S.,et al.Biochim. Biophys. Acta 1131:287-299(1992).
Xanthoudakis S.,et al.EMBO J. 11:3323-3335(1992).
Cheng X.B.,et al.Nucleic Acids Res. 20:370-370(1992).
Gene SymbolAPEX1
Alias SymbolsAPE, APX, APE1, APEN, APEX, HAP1, REF1
NCBI Gene Id328
Description of TargetMultifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'- phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.
Uniprot IDP27695
Molecular Weight36 kDa
  1. What is the species homology for "APEX1 Antibody (OAAB19606)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "APEX1 Antibody (OAAB19606)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "APEX1 Antibody (OAAB19606)" provided in?

    This item is provided in "0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "APEX1 Antibody (OAAB19606)"?

    This target may also be called "APE, APX, APE1, APEN, APEX, HAP1, REF1" in publications.

  5. What is the shipping cost for "APEX1 Antibody (OAAB19606)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "APEX1 Antibody (OAAB19606)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "APEX1 Antibody (OAAB19606)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "36 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "APEX1 Antibody (OAAB19606)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "APEX1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "APEX1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "APEX1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "APEX1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "APEX1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "APEX1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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