APEX1 Antibody (Acetyl-Lys6) (OASG06314)

Catalog No: OASG06314

Size:100 uL

Western Blot using A549

Western Blot using A549

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the human Ref-1 around the acetylation site of K6.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Acetyl-Lys6
• Specificity: Acetyl-Ref-1 (K6) Polyclonal Antibody detects endogenous levels of Ref-1 protein only when acetylated at K6.
• Application Info: WB 1:500-1:2000; IHC-P 1 100-300 ELISA 1:20000;

Target Info

• Gene Symbol: APEX1
• Gene Full Name: APEX nuclease (multifunctional DNA repair enzyme) 1
• Alias Symbols: APE, APX, APE1, APEN, APEX, HAP1, REF1
• NCBI Gene Id: 328;
• Description of Target: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
• Uniprot ID: P27695
• Molecular Weight: 35 kDa