APEH Antibody - middle region (ARP48182_P050)

Catalog No: ARP48182_P050

WB Suggested Anti-APEH Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: NCI-H226 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human APEH
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 92%
• Peptide Sequence: Synthetic peptide located within the following region: GSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHFDASHVALMGGSH
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-APEH (ARP48182_P050) antibody is Catalog # AAP48182 (Previous Catalog # AAPP28691)

Target Info

• Gene Symbol: APEH
• Gene Full Name: N-acylaminoacyl-peptide hydrolase
• Alias Symbols: APH, OPH, AARE, ACPH, D3S48E, D3F15S2, DNF15S2
• NCBI Gene Id: 327
• Protein Name: Acylamino-acid-releasing enzyme
• Description of Target: APEH is the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.
• Uniprot ID: P13798
• Protein Accession #: NP_001631
• Nucleotide Accession #: NM_001640
• Protein Size (# AA): 732
• Molecular Weight: 81kDa
• Protein Interactions: IST1; UBC; LGALS8; APEH; SNX6; CAND1; TOLLIP; CYHR1; JMJD6; HSPA4L; IPO7; DNM1L; VPS26A; NMI; H1FX; ZYX; TBCD; TARS; STAT1; SHMT2; SHMT1; PPM1G; SERPINE2; PAWR; LAMP2; KARS; HIST1H1C; GARS; CTTN; CARS; PREPL; SHBG; UBA5; TMEM62;