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| Datasheets/Manuals | Printable datasheet for Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)OAED00364 |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Clonality | Monoclonal |
| Clone | Sebi-1 |
| Isotype | IgG2a |
| Host | Rat |
| Application | IP, WB |
| Reconstitution and Storage | Long Term Storage : -20C Short Term Storage : +4C Handling : Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -20C. |
| Immunogen | Recombinant human TIRAP (Mal) (aa 1-215). |
| Concentration | 1mg/ml |
| Specificity | Recognizes human TIRAP (Mal). |
| Formulation | Liquid. In PBS containing 0.02% sodium azide. |
| Purity | ≥95% (SDS-PAGE) |
| Application Info | Immunoprecipitation (1:200) Western Blot (1:500) |
| Reference | Inferences, questions and possibilities in Toll-like receptor signalling: B. Beutler; Nature 430, 257 (2004), Abstract; TIRAP: an adapter molecule in the Toll signaling pathway: T. Horng, et al.; Nat. Immunol. 2, 835 (2001), Abstract; Full Text |
| Gene Symbol | TIRAP |
|---|---|
| Alias Symbols | Mal, wyatt, BACTS1, MyD88-2 |
| NCBI Gene Id | 114609 |
| Protein Name | Toll/interleukin-1 receptor domain-containing adapter protein |
| Description of Target | Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading pathogens. Recognition of microbial components by TLRs triggers activation of the innate immune system. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Trif (TIR-domain-containing adaptor inducing interferon-beta), TIRAP (TIR domain-containing adaptor protein)/Mal (MyD88 adaptor-like), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). MyD88 is common to all TLR-mediated pathways, which lead to the production of inflammatory cytokines, whereas TRIF mediates induction of IFN-beta in TLR3 and TLR4 signalling pathways. TIRAP/Mal is implicated in the TLR2- and TLR4-mediated MyD88-dependent signalling pathway. TRAM is specifically involved in the TLR4-mediated TRIF-dependent pathway. Thus, TIR domain-containing adaptors provide specificity of TLR signalling. |
| Uniprot ID | P58753 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 week".
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What buffer format is "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)"?
This target may also be called "Mal, wyatt, BACTS1, MyD88-2" in publications.
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What is the shipping cost for "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Anti-TIRAP (human) (Sebi-1) Antibody (OAED00364)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TIRAP"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TIRAP"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TIRAP"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TIRAP"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TIRAP"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TIRAP"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
