Anti-Thyroid Hormone Receptor, beta -Isotype (OAPC00014)

Catalog No: OAPC00014 (Formerly GWB-7413A2)

Size:100 ul

Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR- beta protein.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
• Clonality: Monoclonal
• Clone: 2386
• Isotype: IgG¹
• Host: Mouse
• Application: WB
• Additional Information: Packaging :
  100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
• Reconstitution and Storage: Store at -20C; stable for at least 1 year.
• Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, beta -isotype.
• Purification: Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.
• Predicted Homology Based on Immunogen Sequence: Human
• Specificity: Specific for the ~55k TR- beta protein.
• Application Info: The antibody has been directly tested for reactivity in Western blots with human tissue.
  Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR- beta protein.
  
• Reference: Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G (2005) Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 81:244-253.
  Chan S, Kilby MD (2000) Thyroid hormone and central nervous system development. J Endocrinol 165:1-8.
  Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Mol Cell Biochem 278:93-100.

Target Info

• Gene Symbol: THRB
• Alias Symbols: GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA
• NCBI Gene Id: 7068
• Protein Name: Thyroid hormone receptor beta
• Description of Target: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha 1, TR alpha 2, TR beta 1 and TR beta 2. TR alpha 1, TR beta 1 and TR beta 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
• Uniprot ID: P10828
• Protein Accession #: NP_000452.2
• Molecular Weight: ~55kDa