Anti-TAFA2 Antibody (OAAI00405)

Catalog No: OAAI00405

Size:100UG

Western Blot: The whole cell lysate derived from mouse brain tissue was immunoblotted Rabbit anti-TAFA2 (Cat#OAAI00405) at 1:500. An immunoreactive band band around 12 kDa was observed.

IHC: Human brain tissue was immune-stained with Anti-TAFA2 antibody, (Cat#OAAI00405) at 1:100 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
• Additional Information: Background: The TAFA2, also known as FAM19A2, is a secreted 12kDa protein. It belongs to the FAM19/TAFA family of chemokinelike. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. TAFAs are highly expressed in central nervous system (CNS), and less extent in other tissues such as colon, heart, lung, spleen, kidney, and thymus. TAFA2 is expression is highest in the occipital and frontal cortex. TAFAs may modulate immune responses in the CNS by functioning as brainspecific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. It may act as neurokines that regulates immune nervous cells . It may also control axonal sprouting following brain injury.
  Positive Control: Brain tissue
  Cellular Location: Extracellular or cytoplasmic
• Reconstitution and Storage: The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
• Immunogen: A synthetic peptide corresponding to the N-terminus of TAFA2 protein. This sequence is identical among human, mouse.
• Purification: Affinity Purified
• Concentration: 100ug/200ul
• Specificity: TAFA2
• Formulation: This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Application Info: WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested
• Reference: Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Genomics. 2004 Apr;83(4):727-34.
  

Target Info

• Gene Symbol: TAFA2
• Gene Full Name: TAFA chemokine like family member 2
• Alias Symbols: chemokine-like protein TAFA-2;FAM19A2;family with sequence similarity 19 (chemokine (C-C motif)-like), member A2;family with sequence similarity 19 member A2, C-C motif chemokine like;protein FAM19A2;TAFA-2.
• NCBI Gene Id: 338811
• Description of Target: The TAFA2, also known as FAM19A2, is a secreted 12kDa protein. It belongs to the FAM19/TAFA family of chemokinelike. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. TAFAs are highly expressed in central nervous system (CNS), and less extent in other tissues such as colon, heart, lung, spleen, kidney, and thymus. TAFA2 is expression is highest in the occipital and frontal cortex. TAFAs may modulate immune responses in the CNS by functioning as brainspecific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. It may act as neurokines that regulates immune nervous cells . It may also control axonal sprouting following brain injury.
  
• Uniprot ID: Q8N3H0
• Molecular Weight: 12