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Catalog No: OAPC00068
Size:100 ul
Price: $390.00
SKU
OAPC00068
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for OAPC00068
Product Info
Predicted Species ReactivityHuman, Rat, Pig
Product FormatLiquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
ClonalityMonoclonal
CloneSP8
IsotypeIgG1
HostMouse
ApplicationWB, IHC
Additional InformationPackaging :
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution and StorageStore at -20C; stable for at least one year.
ImmunogenSynaptic immunoprecipitate (crude) from human brain.
PurificationProtein G purified culture supernatant.
Predicted Homology Based on Immunogen SequenceHuman; Pig; Rat
SpecificityThe antibody is specific for the ~ 36 kDa syntaxin protein in Western blots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. Does not work on paraffin sections.
Application InfoThe antibody has been directly tested for reactivity in human, rat, pig, and hamster.
Western blot of rat cortex lysate showing specific immunolabeling of the ~ 36k syntaxin 1A protein.
ReferenceKhvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC (2007) Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci. 2007 Nov 7;27(45):12147-55
Castillo MA, Ghose S, Tamminga CA, Ulery-Reynolds PG (2010) Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex. Biol Psychiatry. 67(3):208-16
Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Research 609, 9-20 (1993).
Gene SymbolSTX1A
Alias SymbolsSTX1, HPC-1, P35-1, SYN1A
NCBI Gene Id6804
Protein NameSyntaxin-1A
Description of TargetSyntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
Uniprot IDQ16623
Protein Accession #NP_001159375.1
Molecular Weight~36kDa
  1. What is the species homology for "Anti-Syntaxin 1A (OAPC00068)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Rat, Pig".

  2. How long will it take to receive "Anti-Syntaxin 1A (OAPC00068)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Anti-Syntaxin 1A (OAPC00068)" provided in?

    This item is provided in "Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti-Syntaxin 1A (OAPC00068)"?

    This target may also be called "STX1, HPC-1, P35-1, SYN1A" in publications.

  5. What is the shipping cost for "Anti-Syntaxin 1A (OAPC00068)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti-Syntaxin 1A (OAPC00068)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti-Syntaxin 1A (OAPC00068)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "~36kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti-Syntaxin 1A (OAPC00068)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "STX1A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "STX1A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "STX1A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "STX1A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "STX1A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "STX1A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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