Catalog No: OAPC00062 (Formerly GWB-353D30)
Size:10 ug
Price: $390.00
SKU
OAPC00062
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for OAPC00062
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatLyophilized 5mM ammonium bicarbonate. Adequate amount of material to conduct 10 mini Western blots.
ClonalityPolyclonal
HostRabbit
ApplicationWB, IF, IP, IHC
Reconstitution and StorageThe lyophilized antibody can be stored at -20°C and is stable for at least 2 years. The antibody should be reconstituted in 50 uL PBS (PBS: 137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4 pH 7.4) before use. After reconstitution, the antibody should be aliquoted and stored at -20°C.
ImmunogenNative protein purified from bovine brain.
PurificationPrepared from rabbit serum by affinity purification using a column to which the native protein was coupled.
SpecificitySpecific for the ~78k synapsin I doublet in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody.
Application InfoDB: 1:1000
IHC: 1:2000
IF: 1:2000
IP: 1 ug per 200 ug lysate
WB: 1:1000
ReferenceFeng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Ferreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci 22:4372-4380.
Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Jr., Greengard P, Czernik AJ (2001) Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals. J Neurosci 21:7944-7953.
Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P (2002) A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Nature Neurosci 5:431-437.
Moore RY, Bernstein M (1989) Synaptogenesis in the rat suprachiasmatic nucleus demonstrated by electron microscopy and synapsin I immunoreactivity. J Neurosci 9:2151-2162.
Nayak AS, Moore CI, Browning MD (1996) CaM kinase II phosphorylation of the presynaptic protein synapsin is persistently increased during expression of long-term potentiation. Proc Natl Acad Sci (USA) 93:15451-15456.
Stone LM, Browning MD, Finger TE (1994) Differential distribution of the synapsins in the rat olfactory bulb. J Neurosci 14:301-309.
Kurtis D. Davies, Susan M. Goebel-Goody, Steven J. Coultrap, and Michael D. Browning (2008) Long Term Synaptic Depression That Is Associated with GluR1 Dephosphorylation but Not alpha -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Internalization J. Biol. Chem., 283: 33138 - 33146.
Note: Dr. Michael Browning, co-author of the cited papers is the President and founder PhosphoSolutions.
Gene SymbolSYN1
NCBI Gene Id281510
Protein NameSynapsin-1
Description of TargetSynapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989; Stone et al., 1994). Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002).
Uniprot IDP17599
Protein Accession #NP_776616.1
Molecular Weight~78kDa
  1. What is the species homology for "Anti-Synapsin I (OAPC00062)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "Anti-Synapsin I (OAPC00062)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Anti-Synapsin I (OAPC00062)" provided in?

    This item is provided in "Lyophilized 5mM ammonium bicarbonate. Adequate amount of material to conduct 10 mini Western blots.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti-Synapsin I (OAPC00062)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "Anti-Synapsin I (OAPC00062)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti-Synapsin I (OAPC00062)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti-Synapsin I (OAPC00062)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "~78kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti-Synapsin I (OAPC00062)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SYN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SYN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SYN1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SYN1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SYN1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SYN1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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