Anti-SOCS-5 Polyclonal Antibody (OAAI00007)

Catalog No: OAAI00007

Size:100UG

Western Blot: The tissue lysates derived from mouse liver was immunoprobed by Rabbit anti-SCOS-5 (cat#OAAI00007) at 1:500. An immunoreactive band is observed around ~60 kDa.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
• Additional Information: Background: Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS5 regulates IL-4 signaling through JAK1 negatively.
  Positive Control: Endometrium tissue
  Cellular Location: Cytoplasm
• Reconstitution and Storage: The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
• Immunogen: A synthetic peptide corresponding to the C-terminus of SOCS-5 protein from human, mouse and rat origins
• Purification: Affinity Purified
• Concentration: 100ug/200ul
• Specificity: SOCS5
• Formulation: This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Application Info: WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: Not tested | FC: Not tested
• Reference: Sandra E Nicholson, et al. Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. PNAS; PNAS February 15, 2005 vol. 102 no. 7 2328-2333.
  

Target Info

• Gene Symbol: SOCS5
• Gene Full Name: suppressor of cytokine signaling 5
• Alias Symbols: CIS6;CIS-6;Cish5;CISH6;cytokine-inducible SH2 protein 6;cytokine-inducible SH2-containing protein 5;SOCS-5;suppressor of cytokine signaling 5.
• NCBI Gene Id: 9655
• Description of Target: Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS5 regulates IL-4 signaling throμgh JAK1 negatively.
  
• Uniprot ID: O75159
• Molecular Weight: 60