Anti-PKG Antibody (OAED00093)

Catalog No: OAED00093

Size:50 ug

Western blot analysis: Lane 1: MW marker; Lane 2: HeLa cell lysate; Lane 3: Rat brain tissue extract; Lane 4: MDBK cell lysate.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Bovine
• Clonality: Polyclonal
• Host: Rabbit
• Application: ICC, IHC, IP, WB
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Synthetic peptide corresponding to a portion of human PKG1beta, with the subsitiution of a tryptophan residue for tyrosine at residue 9.
• Specificity: Recognizes human, mouse, rat and bovine PKG. Detects a band of ~80kDa by Western blot.
• Formulation: Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
• Purity: Peptide affinity purified.
  
• Application Info: Immunocytochemistry
  Immunohistochemistry
  Immunoprecipitation
  Western Blot (1:1000, ECL)
  Optimal conditions must be determined individually for each application.
• Reference: Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle: J.M. Simard, et al. ; Circ. Res. 93, 805 (2003), Application(s): IHC, WB using rat samples, Abstract;
  Protein kinase G activation of K(ATP) channels in human-cultured prostatic stromal cells: J.M. Haynes, et al. ; Cell. Signal. 14, 1023 (2002), Application(s): ICC using human samples, Abstract;
  Exisulind induction of apoptosis involves guanosine 3,5-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin: R. Pamukcu, et al. ; Cancer Res. 60, 3338 (2000), Application(s): WB using human samples, Abstract;
  

Target Info

• Gene Symbol: PRKG1
• Alias Symbols: PKG, cGK, AAT8, PKG1, cGK1, cGKI, cGK 1, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha
• NCBI Gene Id: 5592
• Protein Name: cGMP-dependent protein kinase 1
• Description of Target: Cyclic GMP-dependent protein kinases (PKGs or cGKs) are classified into two types, PKGI and PKGII. Studies have shown that PKGs are highly homologous to PKAs; phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility, and platelet aggregation.
• Uniprot ID: Q13976