Anti-Pdcd4 pS457 Antibody (OARA02821)

Catalog No: OARA02821

Size:1MG

Product Info

• Predicted Species Reactivity: Artiopoda|Human|Mouse|Rat
• Product Format: Liquid (sterile filtered)
• Clonality: Monoclonal
• Clone: 2E10.C12
• Host: Mouse
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry|Multiplex assay|Western blot
• Additional Information: Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
  Label: Unconjugated
  Preservative: 0.01% (w/v) Sodium Azide
  Stabilizer: None
• Reconstitution and Storage: Store vial at -20 C prior to opening.   This product is stable for several weeks at 4 C as an undiluted liquid.   Dilute only prior to immediate use.   For extended storage aliquot contents and freeze at -20 C or below.   Avoid cycles of freezing and thawing.   Expiration date is one (1) year from date of opening product.
• Immunogen: Anti-Pdcd4 phospho S457 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein.
• Concentration: 1 mg/ml
• Application Info: ELISA: 1:400,000 WB: 1:1,000-1:3,000 IHC: 1.25-2.5 ug/mL
• Reference: Jansen AP, Camalier CE, Colburn NH (2005) Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res. 65(14):6034-6041.Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y (2005) Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. Cancer Res. 65 (24):11282-11286.

Target Info

• Gene Symbol: PDCD4
• Gene Full Name: programmed cell death 4
• Alias Symbols: H731;neoplastic transformation inhibitor protein;nuclear antigen H731;Nuclear antigen H731-like;programmed cell death 4 (neoplastic transformation inhibitor);programmed cell death protein 4;protein 197/15a.
• NCBI Gene Id: 27250
• Protein Name: Programmed cell death protein 4
• Description of Target: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
• Uniprot ID: Q53EL6