Anti-Pax3 (C2) Antibody (OAED00021)

Catalog No: OAED00021

Size:100 ug

Western blot analysis of 624 Mel nuclear lysates probed with Pax-3 mAb (C2) at 1 ug/ml

IHC Analysis: Human skeletal muscle tissue stained with Pax3, mAb (C2) at 10 ug/ml.

IHC Analysis: Human skin tissue stained with Pax3, mAb (C2) at 10 ug/ml.

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: C2
• Isotype: IgG2a
• Host: Mouse
• Application: IHC, WB
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Synthetic peptide corresponding to the sequence near the C-terminus of quail Pax3.
• Specificity: Recognizes human Pax3. Detects a band of ~53kDa by Western blot.
• Formulation: Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
• Purity: Protein G affinity purified.
  
• Application Info: Immunohistochemistry (paraffin sections)
  Western Blot (1μg/ml, ECL)
  Optimal conditions must be determined individually for each application.

Target Info

• Gene Symbol: PAX3
• Alias Symbols: WS1, WS3, CDHS, HUP2
• NCBI Gene Id: 5077
• Protein Name: Paired box protein Pax-3
• Description of Target: Pax3 is a member of the paired box family of nuclear transcription factors that function in the transcriptional control of pattern development during embryogenesis. Pax3 is characterized by a conserved N-terminal paired box DNA binding domain, and a C-terminal transcriptional activation domain. In humans, loss of function mutations in Pax3 are associated with type I and type III Waardenburg Syndrome, characterized by varying degrees of developmental abnormalities in facial structure, pigmentation, limb development, and hearing. Translocation t(2;13) of the Pax3 loci to the fork head (FKHR) transcription factor gene results in the creation of a Pax3-FKHR fusion gene with transcriptional hyperactivity manifested in alveolar rhabdomyosarcoma.
• Uniprot ID: P23760