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Catalog No: OAAI00711
Size:100UG
Price: $449.00
SKU
OAAI00711
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid. This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
ClonalityPolyclonal
IsotypeRabbit IgG
HostRabbit
ApplicationELISA, FC, IHC-Fr, IHC-P, WB
Additional InformationBackground: The MEK5 (also known as MKK5, MAPKK5, SKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. It catalyzes tyrosine phosphorylation of ERK5 whereas MEK5 itself is regulated by MEKK3. An important link between MEK5 and metastatic prostrate cancer has been demonstrated. Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation.
::Positive Control: EGF-stimulated A431
::Cellular Location: Cytoplasmic
Reconstitution and StorageThe antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
ImmunogenA synthetic peptide surrounding the epitope -SIAKT- with double phosphorylation sites Ser311 and Thr315. This sequence is identical among human, rat, mouse, chicken, and dog.
PurificationAffinity Purified
Concentration100ug/200ul
Target Post-Translational ModificationPhosphorylated
SpecificityMAP2K5
FormulationThis affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
Application InfoWB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested
ReferenceTetsuro Shishido, et al. Effects of MEK5/ERK5 Association on Small Ubiquitin-Related Modification of ERK5: Implications for Diabetic Ventricular Dysfunction After Myocardial Infarction. Circulation Research. 2008; 102:1416.
Gene SymbolMAP2K5
Gene Full Namemitogen-activated protein kinase kinase 5
Alias Symbolsdual specificity mitogen-activated protein kinase kinase 5;HsT17454;MAP kinase kinase 5;MAP kinase kinase MEK5b;MAPK/ERK kinase 5;MAPKK 5;MAPKK5;MEK 5;MEK5;PRKMK5.
NCBI Gene Id5607
Description of TargetThe MEK5 (also known as MKK5, MAPKK5, SKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. It catalyzes tyrosine phosphorylation of ERK5 whereas MEK5 itself is regulated by MEKK3. An important link between MEK5 and metastatic prostrate cancer has been demonstrated. Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation.
Uniprot IDQ13163
Molecular Weight49
  1. What is the species homology for "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)" provided in?

    This item is provided in "Liquid. This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)"?

    This target may also be called "dual specificity mitogen-activated protein kinase kinase 5;HsT17454;MAP kinase kinase 5;MAP kinase kinase MEK5b;MAPK/ERK kinase 5;MAPKK 5;MAPKK5;MEK 5;MEK5;PRKMK5." in publications.

  5. What is the shipping cost for "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "49".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific) (OAAI00711)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "MAP2K5"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MAP2K5"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MAP2K5"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MAP2K5"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MAP2K5"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MAP2K5"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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