Anti-HBc Antibody (Core Antigen) (OAAI00128)

Catalog No: OAAI00128

Size:100UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
• Additional Information: Background: The strain of human hepatitis B virus causes severe damage in liver. The Hepatitis B core antibody is the earliest antibody to develop in response to acute hepatitis B virus infection. The anti-HBc typically persists for life, The serologic heterogeneity of the hepatitis B virus (HBV) has been established from immunodiffusion experiments for a long time. With the combination of detecting HBc, HBs, HBe and the antibodies, the results provide clinical evaluation in blood donation, vaccination, etc.
  Positive Control: Hepatitis B Core Antigen
  Cellular Location: Nuclei of infected cells
• Reconstitution and Storage: The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
• Immunogen: A synthetic peptide derived from internal sequence (31-178aa) of human hepatitis B Core Antigen
• Purification: Affinity Purified
• Concentration: 100ug/200ul
• Specificity: C
• Formulation: This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Application Info: WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested
• Reference: Okamoto,H., Imai,M., Shimozaki,M., Hoshi,Y., Iizuka,H., Gotanda,T., Tsuda,F., Miyakawa,Y. and Mayumi,M. Nucleotide sequence of a cloned hepatitis B virus genome, subtype ayr: comparison with genomes of the other three subtypes. J. Gen. Virol. 67 (PT 11), 2305-2314 (1986)
  Magnius LO, Norder H. Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology. 1995;38(1-2):24-34. Review
  Magnius LONorder HStahl S, MacKay P, Magazin M, Bruce SA, Murray K. Hepatitis B virus core antigen: Synthesis in Escherichia coli and application in diagnosis. Proc Natl Acad Sci 1982;79(5):1606-10 Tiollais P, Pourcel C, Dejean A. The hepatitis B virus. Nature 1985;317(6037):489-95.
  
• Publications:

  Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly. Nat Commun. 10, 2184 (2019). 31097716

• Description:
  View product citations for Anti-HBc Antibody (Core Antigen) (OAAI00128) on CiteAb

Target Info

• Gene Symbol: C
• Gene Full Name: capsid protein;pre-capsid protein
• Alias Symbols: capsid protein;pre-capsid protein;HBVgp4.
• NCBI Gene Id: 944568
• Description of Target: The strain of Human hepatitis B virus causes severe damage in liver. The Hepatitis B core Antibody is the earliest Antibody to develop in response to acute hepatitis B virus infection. The anti-HBc typically persists for life, The serologic heterogeneity of the hepatitis B virus (HBV) has been established from immunodiffusion experiments for a long time. With the combination of detecting HBc, HBs, HBe and the antibodies, the results provide clinical evaluation in blood donation, vaccination, etc.
  
• Molecular Weight: 1.5