Anti-GluR6/7 Polyclonal Antibody (OAAI00175)

Catalog No: OAAI00175

Size:100UG

IHC: Human brain tissue stained with Anti -GluR6/7 antibody, Cat#OAAI00175 at 1:50 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
• Additional Information: Background: Glutamate receptors (GluR) are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1- 3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors. GluR6 belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Mutations in this gene have been associated with autosomal recessive mental retardation.
  Positive Control: Brain
  Cellular Location: Cytoplasmic/Membrane
• Reconstitution and Storage: The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
• Immunogen: A synthetic peptide derived from C-terminus of Glutamate receptor 6/7 Protein. This sequence is identical to human, mouse and rat.
• Purification: Affinity Purified
• Concentration: 100ug/200ul
• Specificity: GRIK2
• Formulation: This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Application Info: WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested
• Reference: Pickering,D.S., Taverna,F.A., Salter,M.W. and Hampson,D.R. Palmitoylation of the GluR6 kainate receptor.
  Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12090-12094 (1995).
  

Target Info

• Gene Symbol: GRIK2
• Gene Full Name: glutamate ionotropic receptor kainate type subunit 2
• Alias Symbols: bA487F5.1;EAA4;excitatory amino acid receptor 4;GLR6;GluK2;GluK2(alt_5'UTR);GLUK6;gluR-6;GLUR6;glutamate receptor 6;glutamate receptor form A;glutamate receptor form B;glutamate receptor form C;glutamate receptor form D;glutamate receptor form E;glutamate receptor ionotropic, kainate 2;MRT6;putative NMDtranscript(cassette_171nt).
• NCBI Gene Id: 2898
• Description of Target: Glutamate receptors (GluR) are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1- 3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors. GluR6 belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thoμght to alter the structure and function of the receptor complex.
  Mutations in this gene have been associated with autosomal recessive mental retardation.
  
• Uniprot ID: Q13002
• Molecular Weight: 100