Size:100 ul
$269.00
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SKU
OAPC00115
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Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)

Catalog#: OAPC00115
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species Reactivity Human, Mouse, Rat
Product Format Liquid. 10mM sodium azide.
Clonality Polyclonal
Host Chicken
Application WB, IF
Reconstitution and Storage Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Replacement Item This antibody may replace item sc-115582 from Santa Cruz Biotechnology.
Immunogen Recombinant and purified bovine GFAP.
Purification Total IgY fraction.
Predicted Homology Based on Immunogen Sequence Human; Mouse; Rat
Datasheets/Manuals Printable datasheet for OAPC00115
Specificity Specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule.
Application Info The antibody has been directly tested for reactivity in human, mouse and rat. It is expected that the antibody will react with other mammalian tissues.
Western blot of rat cortex lysate showing specific immunolabeling of the ~ 50k GFAP protein.
Mixed cultures of neurons and glia stained with chicken anti-GFAP (red), and DNA (blue). Astrocytes stain strongly and specifically in a clearly filamentous fashion with this antibody.
Target Reference 1. Bignami A, Eng LF, Dahl D, Uyeda CT. Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res. 43:429-35 (1972).
2. Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE and Messing A. Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet 27:117-20 (2001)
Gene Symbol GFAP
NCBI Gene Id 281189
Protein Name Glial fibrillary acidic protein
Description of Target Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2).
Swissprot Id Q28115
Protein Accession # NP_776490.2
Molecular Weight ~50kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express GFAP.
RNA Seq Find tissues and cell lines supported by DNA array analysis to express GFAP.
  1. What is the species homology for "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)" provided in?

    This item is provided in "Liquid. 10mM sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "~50kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti-Glial Fibrillary Acidic Protein (GFAP) (OAPC00115)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "GFAP"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GFAP"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GFAP"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GFAP"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GFAP"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GFAP"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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