Anti-FADD Antibody (OAED00046)

Catalog No: OAED00046

Size:50 ug

Western blot analysis: Lane 1: MW marker; Lane 2: HeLa.

IHC Analysis: Human kidney tissue stained with FADD, pAb at 10 ug/ml.

IHC Analysis: Human placenta tissue stained with FADD, pAb at 10 ug/ml.

Product Info

• Predicted Species Reactivity: Human, Rat, Monkey
• Product Format: Liquid. PBS, pH 7.2 containing 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Application: ICC, IHC, WB
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Synthetic peptide corresponding to a portion of human FADD.
• Purification: Peptide affinity purified.
• Specificity: Recognizes human, rat, and monkey FADD. Detects a band of ~28kDa by Western blot.
• Application Info: WB 1:1000
• Reference: Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli: T.R. Billiar, et al. ; J. Biol. Chem. 277, 38855 (2002), Application(s): ICC, WB using rat samples, Abstract;
  B cell receptor cross-linking triggers a caspase-8-dependent apoptotic pathway that is independent of the death effector domain of Fas-associated death domain protein: A. Vazquez, et al. ; J. Immunol. 167, 733 (2001), Application(s): WB using human samples, Abstract;
  

Target Info

• Gene Symbol: Fadd
• Alias Symbols: Mort1/F, Mort1/FADD
• NCBI Gene Id: 14082
• Protein Name: Protein FADD
• Description of Target: Fas-associating death domain containing protein (FADD)/MORT1 serves as a signal transducer of Fas-induced apoptosis. Through its amino-terminal death effector domain (DED), FADD binds to cytosolic proteins such as TRADD, a cytosolic death domaincontaining protein that asssociates with the cytosolic portion of TNF receptor, or MACH/FLICE/caspase-8, a protease with sequence homology to ICE-CED-3 protease family, in order to transduce the death signal.
• Uniprot ID: Q61160