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Anti-EGFR Monoclonal Antibody (OAAI00284)

100 ug
$360.00
In Stock
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Predicted Species Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal
Isotype:
Mouse IgG1
Host:
Mouse
Application:
WB, IP, IHC
Reconstitution and Storage:
The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity.
Avoid repeated freezing thawing cycles.
Gene Symbol:
EGFR
NCBI Gene Id:
1956
Official Gene Full Name:
epidermal growth factor receptor
Swissprot Id:
P00533
Alias Symbols:
ERBB, HER1, mENA, ERBB1, PIG61,
Replacement Item:
This antibody may replace item sc-03, HPA001200, HPA018530
Description of Target:
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Molecular Weight:
~170 kDa (WT), 145 (VIII Variant)
Purification:
The Mouse IgG is purified by Isotyping-specific Affinity Purification.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express EGFR.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express EGFR.
Immunogen:
An Extracellular domain of Human recombinant EGFR protein as an immunogen
Datasheets/Manuals:
Printable datasheet for Mouse Anti-EGFR Monoclonal Antibody OAAI00284
Specificity:
This antibody recognizes EGFR protein. It cross-reacts with Human, Rat and Mouse. The other species was not tested.
Application Info:
Positive Control: Placenta, A431
Western Blot: 0.1-1 μg/ml
ELISA: 0.01-0.1 μg/ml
IP: 2-5 μg/ml
IHC: 2-5 μg/ml
Target Reference:
Davis,R.J. and Czech,M.P. Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal Human fibroblasts at threonine-654. Proc. Natl. Acad. Sci. U.S.A. 82 (7), 1974-1978 (1985)

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