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Catalog No: OAPC00102 (Formerly GWB-C2A0DB)
Size:100 ul
Price: $390.00
SKU
OAPC00102
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for OAPC00102
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatLiquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
ClonalityPolyclonal
HostSheep
ApplicationWB
Additional InformationPackaging :
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution and StorageFor long term storage -20C is recommended. Stable at -20C for at least 1 year.
ImmunogenPeptide from the C-terminal region of human dopamine beta -hydroxylase (DBH), conjugated to keyhole limpet hemocyanin (KLH).
PurificationPrepared from sheep serum by affinity purification using a Sulfo-Link column matrix to which the peptide immunogen was coupled.
Predicted Homology Based on Immunogen SequenceHuman; Mouse
SpecificitySpecific for the ~75k DBH protein in Western blots.
Application InfoThe antibody has been directly tested for reactivity in Western blots with human, mouse, and non-human primate tissue.
Western blot of human adrenal medulla lysate showing specific immunolabeling of the ~75k DBH protein.
ReferenceKish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.
Sabban EL, Kvetnansky R (2001) Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events. Trends Neurosci 24:91-98.
Zhu MY, Klimek V, Haycock JW, Ordway GA (2000) Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain. J Neurosci Meth 99:37-44.
Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA (1999) Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46:1275-1286.
Gene SymbolDBH
Alias SymbolsDBM, ORTHYP1
NCBI Gene Id1621
Protein NameDopamine beta-hydroxylase
Description of TargetDBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. DBH antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). The expression of DBH is also elevated during stress (Sabban and Kvetnansky, 2001).
Uniprot IDP09172
Protein Accession #NP_000778
Nucleotide Accession #NM_000787
Molecular Weight~75kDa
  1. What is the species homology for "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)" provided in?

    This item is provided in "Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)"?

    This target may also be called "DBM, ORTHYP1" in publications.

  5. What is the shipping cost for "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "~75kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti-Dopamine beta -Hydroxylase, C-Terminus (OAPC00102)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "DBH"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "DBH"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "DBH"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "DBH"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "DBH"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "DBH"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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