- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for OAPC00092 |
---|
Predicted Species Reactivity | Human, Mouse, Rat |
---|---|
Product Format | Liquid. 100 ul in PBS + 50% glycerol. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB, ICC |
Additional Information | Packaging : 100 ul in PBS + 50% glycerol. |
Reconstitution and Storage | Store at -20C in undiluted aliquots; stable for up at least 1 year after date of receipt. Avoid freeze/thaw cycles. |
Immunogen | Synthetic peptide taken from the C-terminus of rat clavesin 1. |
Purification | Prepared from serum by affinity purification using a column to which the peptide antigen was coupled. |
Predicted Homology Based on Immunogen Sequence | Human; Mouse; Rat |
Specificity | Specific for the ~ 35 kDa clavesin 1/2 protein doublet in Western blots of rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively. |
Application Info | The antibody has been directly tested for reactivity in rat. It is anticipated that the antibody will also work in human and mouse as there is 100% homology in these species with the amino acid sequence used as antigen. Western blot of rat hippocampal homogenate showing specific immunolabeling of the ~ 35k clavesin protein. |
Reference | Yohei Katoh, Brigitte Ritter, Thomas Gaffry, Francois Blondeau, Stefan Höning and Peter S. McPherson (2009) the clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. Journal of Biological Chemistry Oct 2;284(40):27646-54. Zhao S, Xu C, Qian H, Lv L, Ji C, Chen C, Zhao X, Zheng D, Gu S, Xie Y, Mao Y (2008) Cellular retinaldehyde-binding protein-like (CRALBPL), a novel human Sec14p-like gene that is upregulated in human hepatocellular carcinomas, may be used as a marker for human hepatocellular carcinomas. DNA Cell Biol. Mar; 27(3):159-63. |
Gene Symbol | CLVS1/2 |
---|---|
Alias Symbols | Rlbp1l1, Clavesin-1, RGD1564200 |
NCBI Gene Id | 366311 |
Protein Name | Clavesin-1 |
Description of Target | Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008). |
Uniprot ID | A6JFQ6 |
Protein Accession # | NP_001102439.1 |
Molecular Weight | ~35kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "Anti-Clavesin 1/2 (OAPC00092)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".
-
How long will it take to receive "Anti-Clavesin 1/2 (OAPC00092)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
-
What buffer format is "Anti-Clavesin 1/2 (OAPC00092)" provided in?
This item is provided in "Liquid. 100 ul in PBS + 50% glycerol.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Anti-Clavesin 1/2 (OAPC00092)"?
This target may also be called "Rlbp1l1, Clavesin-1, RGD1564200" in publications.
-
What is the shipping cost for "Anti-Clavesin 1/2 (OAPC00092)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "Anti-Clavesin 1/2 (OAPC00092)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "Anti-Clavesin 1/2 (OAPC00092)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "~35kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Anti-Clavesin 1/2 (OAPC00092)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "CLVS1/2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "CLVS1/2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "CLVS1/2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "CLVS1/2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "CLVS1/2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "CLVS1/2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.