Anti-C-Rel Antibody (Phospho-Ser503) (OAAI00079)

Catalog No: OAAI00079

Size:100UG

WB: The cell lysate derived from PMA treated Jurkate cells was immunoprobed by Rabbit anti -c -Rel (p S503) (Cat#OAAI00079) at 1:500. A major immunoreactive band is observed around ~ 68 kDa.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid. This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
• Additional Information: Background: The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA, RELB, NFKB1, and NFKB2. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor. C-Rel protooncogene can be formed immune complexes with othe proteins such as p105, p50 NFKB under phosphorylation status
  Positive Control: PMA-treated Jurkat cells
  Cellular Location: Nucleus. Cytoplasm.
• Reconstitution and Storage: The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
• Immunogen: A synthetic peptide corresponding to the epitope -TTSSDS-at a phosphorylation site Ser503 of human c-Rel protein. This sequence is identical within human and mouse.
• Purification: Affinity Purified
• Concentration: 100ug/200ul
• Target Post-Translational Modification: Phosphorylated
• Specificity: REL
• Formulation: This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
• Application Info: WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested
• Reference: Neumann,M., Tsapos,K., Scheppler,J.A., Ross,J. and Franza,B.R. Jr. Identification of complex formation between two intracellular tyrosine kinase substRates: Human c-Rel and the p105 precursor of p50 NF-kappa B. Oncogene 7 (11), 2095- 2104 (1992).
  

Target Info

• Gene Symbol: REL
• Gene Full Name: REL proto-oncogene, NF-kB subunit
• Alias Symbols: C-Rel;HIVEN86A;oncogene REL, avian reticuloendotheliosis;proto-oncogene c-Rel;v-rel avian reticuloendotheliosis viral oncogene homolog.
• NCBI Gene Id: 5966
• Description of Target: The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA, RELB, NFKB1, and NFKB2. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor. C-Rel protooncogene can be formed immune complexes with othe proteins such as p105, p50 NFKB under phosphorylation status.
• Uniprot ID: Q04864
• Molecular Weight: 68