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Catalog No: OAAI00597
Size:100UG
Price: $399.00
SKU
OAAI00597
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid. This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
ClonalityPolyclonal
IsotypeRabbit IgG
HostRabbit
ApplicationELISA, FC, IHC, IP, WB
Additional InformationBackground: Beta-catenin is a cytosolic, 88 kDa, 781 amino acid protein belongs to the β-catenin family. The N-terminus domain, containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin(s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, β-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3β and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates β-catenin at multiple sites, including S33 and S37, Y96, Y228, Y280 etc. Phosphorylation of β-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3β activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3β, allowing unphosphorylated β-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis.
::Positive Control: Human lung adenocarcinoma
::Cellular Location: Cytoplasm. Nucleus.
Reconstitution and StorageThe antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
ImmunogenA synthetic peptide corresponding to the epitope SGIHS with a single phosphorylation site Ser37 of human -catenin.
PurificationAffinity Purified
Concentration100ug/200ul
Target Post-Translational ModificationPhosphorylated
SpecificityCTNNB1
FormulationThis affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
Application InfoWB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested
ReferencePark, C.S. et al. (2004) J. Biol. Chem. 279:19592.
Gene SymbolCTNNB1
Gene Full Namecatenin beta 1
Alias Symbolsarmadillo;catenin (cadherin-associated protein), beta 1, 88kDa;catenin beta-1;CTNNB;EVR7;MRD19;NEDSDV.
NCBI Gene Id1499
Description of TargetBeta-catenin is a cytosolic, 88 kDa, 781 amino acid protein belongs to the beta-catenin family. The N-terminus domain, containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin(s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, beta-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3beta and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates beta-catenin at multiple sites, including S33 and S37, Y96, Y228, Y280 etc. Phosphorylation of beta-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3beta activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3beta, allowing unphosphorylated beta-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis.
Uniprot IDP35222
Molecular Weight100
  1. What is the species homology for "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)" provided in?

    This item is provided in "Liquid. This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)"?

    This target may also be called "armadillo;catenin (cadherin-associated protein), beta 1, 88kDa;catenin beta-1;CTNNB;EVR7;MRD19;NEDSDV." in publications.

  5. What is the shipping cost for "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "100".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti- Beta -Catenin Antibody (Phospho-S37) (OAAI00597)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CTNNB1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CTNNB1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CTNNB1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CTNNB1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CTNNB1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CTNNB1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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