Anti-APRIL (Sacha-2) Antibody (OAED00345)

Catalog No: OAED00345

Size:100UG

Product Info

• Predicted Species Reactivity: Human|Mouse
• Clonality: Monoclonal
• Clone: Sacha-2
• Isotype: IgG2a
• Host: Rat
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry
• Reconstitution and Storage: Long Term Storage : +4C
  Handling : Do not freeze/thaw.
  Stable for at least 6 months after receipt when stored at +4C undiluted.
• Immunogen: Recombinant human APRIL (aa 105-250) fused to human ACRP30headless (aa 16-108) (Prod. No. ALX-522-035).
• Concentration: 1mg/ml
• Specificity: Recognizes human and mouse APRIL.
• Source: Purified from concentrated hybridoma tissue culture supernatant.
• Formulation: Liquid. In PBS containing 0.02% sodium azide.
• Purity: ≥95% (SDS-PAGE)
• Application Info: ELISA (capture)
  Flow Cytometry
  Immunocytochemistry

Target Info

• Gene Symbol: ADIPOQ|TNFSF13
• Gene Full Name: adiponectin, C1Q and collagen domain containing|TNF superfamily member 13
• Alias Symbols: 30 kDa adipocyte complement-related protein;a proliferation-inducing ligand;ACDC;ACRP30;adipocyte complement-related 30 kDa protein;Adipocyte, C1q and collagen domain-containing protein;adiponectin;adipose most abundant gene transcript 1 protein;adipose specific collagen-like factor;ADIPQTL1;ADPN;APM1;APM-1;APRIL;CD256;GBP28;Gelatin-binding protein;gelatin-binding protein 28;TALL2;TALL-2;TNF- and APOL-related leukocyte expressed ligand 2;TNF-related death ligand 1;TNLG7B;TRDL-1;tumor necrosis factor (ligand) superfamily, member 13;tumor necrosis factor ligand 7B;tumor necrosis factor ligand superfamily member 13;tumor necrosis factor superfamily member 13;tumor necrosis factor-like protein ZTNF2;tumor necrosis factor-related death ligand-1;UNQ383/PRO715;ZTNF2.
• NCBI Gene Id: 8741|9370
• Protein Name: Adiponectin|Tumor necrosis factor ligand superfamily member 13
• Description of Target: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.|Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
• Uniprot ID: O75888|Q15848