Catalog No: OAPC00010
Size:100 ul
Price: $390.00
SKU
OAPC00010
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for OAPC00010
Product Info
Predicted Species ReactivityHuman, Mouse, Cow
Product FormatLiquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
ClonalityMonoclonal
Clone3F4
IsotypeIgG
HostMouse
ApplicationWB, IHC
Additional InformationPackaging :
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution and StorageStore at -20C in undiluted aliquots; stable for up to one year after date of receipt. Avoid freeze/thaw cycles.
ImmunogenPartially purified bovine 220-kDa disc rim protein.
PurificationProtein G purified culture supernatant.
Predicted Homology Based on Immunogen SequenceCow; Human; Mouse
SpecificitySpecific for ABCA4
Application InfoThe antibody has been directly tested for reactivity in bovine, human, mouse and Xenopus tissues.
Immunohistochemical staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.
ReferenceMichelle Illing, Laurie L. Molday and Robert S. Molday. The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily. J. Biol. Chem., (1997) Vol 272 (15) I April 11. 10303-10310.
Klevering BJ, Deutman AF, Maugeri A, Cremers FP, Hoyng CB (2005) The spectrum of retinal phenotypes casued by mutations in the ABCA4 gene. Graefes Arch Clin Exp Ophthalmol. 243(2):90-100.
Molday, L. et al., ABCR expression in foveal cone photoreceptors and its role in Stargardt macular dystrophy. Nature Genetics (2000) 25, 257 - 258.
Wiszniewski, W. et al., ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies. Human Molecular Genetics (2005) 14(19):2769-2778.
Gene SymbolABCA4
Alias SymbolsR, RmP, Abc1, Abcr, Abc10, AW050280, D430003I15Rik
NCBI Gene Id11304
Protein NameRetinal-specific ATP-binding cassette transporter
Description of TargetABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005).
Uniprot IDO35600
Protein Accession #NP_031404.1
Molecular Weight220 kDa
  1. What is the species homology for "Anti-ABCA4 (Rim Protein) (OAPC00010)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Cow".

  2. How long will it take to receive "Anti-ABCA4 (Rim Protein) (OAPC00010)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Anti-ABCA4 (Rim Protein) (OAPC00010)" provided in?

    This item is provided in "Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti-ABCA4 (Rim Protein) (OAPC00010)"?

    This target may also be called "R, RmP, Abc1, Abcr, Abc10, AW050280, D430003I15Rik" in publications.

  5. What is the shipping cost for "Anti-ABCA4 (Rim Protein) (OAPC00010)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti-ABCA4 (Rim Protein) (OAPC00010)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti-ABCA4 (Rim Protein) (OAPC00010)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "220 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti-ABCA4 (Rim Protein) (OAPC00010)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ABCA4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ABCA4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ABCA4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ABCA4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ABCA4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ABCA4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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