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ANO1 Antibody - middle region (OAAB13882)

Catalog#: OAAB13882
Domestic: within 1 week delivery International: 1 week
More Information
Predicted Species ReactivityHuman
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
Additional InformationFunction: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Cellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors
Tissue Location: Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-135235 from Santa Cruz Biotechnology.
ImmunogenThis ANO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human ANO1.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification
Predicted Homology Based on Immunogen SequenceHuman
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/ManualsPrintable datasheet for OAAB13882
Intended UseANO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Application InfoWB: 1:1000

Yin, L. et al. Glucose stimulates calcium-activated chloride secretion in small intestinal cells. Am. J. Physiol. Cell Physiol. 306, C687-96 (2014). WB, Human 24477233

Gene SymbolANO1
Alias SymbolsANO1, DOG1, ORAOV2, TAOS2, TMEM16A, Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2
NCBI Gene Id55107
Protein NameAnoctamin-1
Description of TargetANO1 acts as a calcium-activated chloride channel. Required for normal tracheal development.
Swissprot IdQ5XXA6
Protein Accession #NP_060513.5
Molecular Weight114078 Da
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express ANO1.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express ANO1.
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