Size:400ul
$329.00
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SKU
OAAB13882
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ANO1 Antibody - middle region (OAAB13882)

Catalog#: OAAB13882
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species Reactivity Human
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Clonality Polyclonal
Isotype Ig
Host Rabbit
Application WB
Additional Information Function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Cellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors
Tissue Location: Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-135235 from Santa Cruz Biotechnology.
Immunogen This ANO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human ANO1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification
Predicted Homology Based on Immunogen Sequence Human
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals Printable datasheet for OAAB13882
Intended Use ANO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Application Info WB: 1:1000
Publications

Yin, L. et al. Glucose stimulates calcium-activated chloride secretion in small intestinal cells. Am. J. Physiol. Cell Physiol. 306, C687-96 (2014). WB, Human 24477233

Gene Symbol ANO1
Alias Symbols ANO1, DOG1, ORAOV2, TAOS2, TMEM16A, Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2
NCBI Gene Id 55107
Protein Name Anoctamin-1
Description of Target ANO1 acts as a calcium-activated chloride channel. Required for normal tracheal development.
Swissprot Id Q5XXA6
Protein Accession # NP_060513.5
Molecular Weight 114078 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ANO1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ANO1.
  1. What is the species homology for "ANO1 Antibody - middle region (OAAB13882)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "ANO1 Antibody - middle region (OAAB13882)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "ANO1 Antibody - middle region (OAAB13882)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ANO1 Antibody - middle region (OAAB13882)"?

    This target may also be called "ANO1, DOG1, ORAOV2, TAOS2, TMEM16A, Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2" in publications.

  5. What is the shipping cost for "ANO1 Antibody - middle region (OAAB13882)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ANO1 Antibody - middle region (OAAB13882)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ANO1 Antibody - middle region (OAAB13882)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "114078 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ANO1 Antibody - middle region (OAAB13882)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "ANO1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ANO1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ANO1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ANO1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ANO1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ANO1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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