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ANO1 Antibody - middle region (OAAB13882)

400ul
$390.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid. PBS with 0.09% (W/V) sodium azide.
Clonality:
Polyclonal
Isotype:
Ig
Host:
Rabbit
Application:
WB
Additional Information:
Function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Cellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors
Tissue Location: Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
ANO1
NCBI Gene Id:
55107
Protein Name:
Anoctamin-1
Swissprot Id:
Q5XXA6
Protein Accession #:
NP_060513.5
Alias Symbols:
ANO1, DOG1, ORAOV2, TAOS2, TMEM16A, Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2
Replacement Item:
This antibody may replace item sc-135235 from Santa Cruz Biotechnology.
Description of Target:
ANO1 acts as a calcium-activated chloride channel. Required for normal tracheal development.
Molecular Weight:
114078 Da
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ANO1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ANO1.
Immunogen:
This ANO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human ANO1.
Predicted Homology Based on Immunogen Sequence:
Human
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB13882
Intended Use:
ANO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
WB: 1:1000
Publications:

Yin, L. et al. Glucose stimulates calcium-activated chloride secretion in small intestinal cells. Am. J. Physiol. Cell Physiol. 306, C687-96 (2014). WB, Human 24477233

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