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ANO1 Antibody - C-terminal region (OABB01454)

100 ug
$320.00
In Stock
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Gene Symbol:
ANO1
Official Gene Full Name:
Anoctamin-1
NCBI Gene Id:
55107
Swissprot Id:
Q5XXA6
Alias Symbols:
ANO 1, ANO1, ANO1_HUMAN, Anoctamin 1, Anoctamin 1 calcium activated chloride channel, Anoctamin-1, Anoctamin1, Discovered on gastrointestinal stromal tumors protein 1, DOG 1, FLJ10261, Membrane protein, Oral cancer overexpressed 2, Oral cancer overexpress
Replacement Item:
This antibody may replace item sc-135235 from Santa Cruz Biotechnology.
Description of Target:
Anoctamin-1(ANO1), also known as oral cancer overexpressed 2(ORAOV2) or tumor-amplified and overexpressed sequence 2(TMEM16A), is a protein that in humans is encoded by the ANO1 gene. This gene belongs to a family of membrane proteins containing 8 transmembrane segments, and it is mapped to 11q13.3. ANO1 is a candidate calcium-activated chloride channel that mediates receptor-activated chloride currents in diverse physiologic processes, and it is though to be responsible for a voltage-sensitive calcium-activated chloride current. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression Crofelemer, an antidiarrhoeal, inhibits this channel. ANO1 has eight transmembrane domains, its pore is large and non-selective, allowing other negatively charged species to permeate.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Immunogen affinity purified.
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ANO1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ANO1.
Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human TMEM16A(927-943aa KVLMVELFMREEQDKQQ), different from the related mouse and rat sequences by one amino acid.
Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution and Storage:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. Store at -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Datasheets/Manuals:
Printable datasheet for anti-ANO1 (OABB01454) antibody
Isotype:
IgG
Application Info:
WB: 0.1-0.5ug/ml

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