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Catalog No: OPTA00946
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OPTA00946
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ANGPT2 Protein (OPTA00946)

Datasheets/ManualsPrintable datasheet for OPTA00946
COA DatasheetPrintable COA datasheet for OPTA00946
Product Info
Tested Species ReactivityHuman
Product FormatLyophilized The protein is deposited as a clear and colorless film that is not always visible. Even if the vial appears empty, reconstitute according to instructions below and use as intended.
ApplicationCA
Additional InformationEndotoxin Level: Endotoxin level is <0.1 ng/ug of protein (<1 EU/ug).
Protein Content: Verified by UV Spectroscopy and/or SDS-PAGE gel.
Authenticity: Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Reconstitution and StorageCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to one week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (ex. 0.1% BSA) and store in working aliquots at -20°C to -80°C. Avoid repeated freeze/thaw cycles. Expires 1 year from date of receipt.
Purity95%
Biological ActivityUsing a concentration of 0.2 ug/mL, a tubulogenesis assay with human umbilical vein endothelial cells (HUVECs) is performed.
Protein SequenceDAPLEYDDSV QRLQVLENIM ENNTQWLMKL ENYIQDNMKK EMVEIQQNAV QNQTAVMIEI GTNLLNQTAE QTRKLTDVEA QVLNQTTRLE LQLLEHSLST NKLEKQILDQ TSEINKLQDK NSFLEKKVLA MEDKHIIQLQ SIKEEKDQLQ VLVSKQNSII EELEKKIVTA TVNNSVLQKQ QHDLMETVNN LLTMMSTSNS AKDPTVAKEE QISFRDCAEV FKSGHTTNGI YT
SourceCHO cells
TagC-terminal His tag
Reference

Masonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejeski C, Compton D, McClain J, Aldrich TH et al. 1997. Science. 277(5322): 55-60.

Murdoch C, Tazzyman S, Webster S adn Lewis CE. 2007. J Immunol. 178(11): 7405-7411.

Tsigkos S, Koutsilieris M and Papapetropoulos A. 2003. Expert Opin Investig Drugs. 12(6): 933-941.

Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD and Suda T. 1998. Int Immunol. 10(8):1217-1227.

Singh H, Tahir TA, Alawo DO, Issa E and Brindle NP. 2011. Biochem Soc Trans. 39(6): 1592-1596.

Yuan HT, Khankin EV, Karumanchi SA and Parikh SM. 2009. Mol Cell Biol. 29(8): 2011-2022.

Gene SymbolANGPT2
Gene Full Nameangiopoietin 2
Alias SymbolsANG2, AGPT2
NCBI Gene Id285
Protein Nameangiopoietin-2
Description of TargetThe protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
Molecular Weight50.1 kDa
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