Amiodarone HCl (OOMC00046)

Catalog No: OOMC00046

Size:1 g

Product Info

• Product Format: Powder
• Additional Information: CAS: 19774-82-4
  Molecular Formula: C25H29I2NO3 - HCl
  Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
  Primary Activity: Ion channel antagonist, Autophagy modulator
  COVID-19 Rationale: Suppresses SARS-CoV infection in cells through inhibition of late endosomes
• Reconstitution and Storage: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml). Store at room temperature.
• Purity: > 98%
• Reference: 1) Yamase et al. (2012), Effectiveness of amiodarone verus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomized trial; Heart, 98 1067 2) Di Matola et al. (2000), Amiodrarone induces cytochrome c release and apoptosis through an iodine-independent mechanism; J. Clin. Endocrinol. Metab., 85 4323 3) Capell et al. (2011), Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase; J. Neurosci., 31 1885 4) Lan et al. (2014), Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis; Autophagy, 10 1687

Target Info

• Molecular Weight: 681.77 g/mol