Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP88922_P050
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AMFR Antibody - N-terminal region (ARP88922_P050)

Catalog#: ARP88922_P050
Domestic: within 24 hours delivery | International: 3-5 business days
More Information
Tested Species Reactivity Mouse
Predicted Species Reactivity Mouse
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of mouse AMFR
Purification Affinity purified
Peptide Sequence Synthetic peptide located within the following region: AYRALSQPEDGSGEPEPLTAPLQPEALAPARLTAGGPRARDVAQYLLSDS
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-AMFR (ARP88922_P050) antibody is Catalog # AAP88922
Datasheets/Manuals Printable datasheet for anti-AMFR (ARP88922_P050) antibody
Gene Symbol AMFR
Official Gene Full Name autocrine motility factor receptor
Alias Symbols gp78
NCBI Gene Id 23802
Protein Name E3 ubiquitin-protein ligase AMFR
Description of Target E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity).
Swissprot Id Q9R049
Protein Accession # NP_035917.2
Nucleotide Accession # NM_011787.2
Protein Size (# AA) 643
Molecular Weight 70 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express AMFR.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express AMFR.
  1. What is the species homology for "AMFR Antibody - N-terminal region (ARP88922_P050)"?

    The tested species reactivity for this item is "Mouse". This antibody is predicted to have homology to "Mouse".

  2. How long will it take to receive "AMFR Antibody - N-terminal region (ARP88922_P050)"?

    This item is available "Domestic: within 24 hours delivery | International: 3-5 business days".

  3. What buffer format is "AMFR Antibody - N-terminal region (ARP88922_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "AMFR Antibody - N-terminal region (ARP88922_P050)"?

    This target may also be called "gp78" in publications.

  5. What is the shipping cost for "AMFR Antibody - N-terminal region (ARP88922_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "AMFR Antibody - N-terminal region (ARP88922_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "AMFR Antibody - N-terminal region (ARP88922_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "70 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "AMFR Antibody - N-terminal region (ARP88922_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "AMFR"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "AMFR"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "AMFR"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "AMFR"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "AMFR"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "AMFR"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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