Ambra1 Antibody (OAPB00662)

Catalog No: OAPB00662

Size:100UG

Western blot analysis of Ambra1 in 3T3 cell lysate with Ambra1 antibody at 1 ug/mL.

Immunohistochemistry of Ambra1 in human brain with Ambra1 antibody at 5 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. Ambra1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: Ambra1 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: Ambra1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human Ambra1. The immunogen is located within the last 50 amino acids of Ambra1.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-Ambra1 antibody is Catalog # OEPB02780
• Application Info: Ambra1 antibody can be used for the detection of Ambra1 by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
• Reference: Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene2004; 23:2891-906.;Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis1993; 14:2501-5.;Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature1999; 402:672-6.;Fimia GM, Stoykova A, Romagnoli A, et al. Ambra1 regulates autophagy and development of the nervous system. Nature2007; 447:1121-5.

Target Info

• Gene Symbol: AMBRA1
• Gene Full Name: autophagy and beclin 1 regulator 1
• Alias Symbols: activating molecule in beclin-1-regulated autophagy;activating molecule in BECN1-regulated autophagy protein 1;autophagy/beclin-1 regulator 1;DCAF3;DDB1 and CUL4 associated factor 3;WD repeat domain 94;WDR94.
• NCBI Gene Id: 55626
• Protein Name: Activating molecule in BECN1-regulated autophagy protein 1
• Description of Target: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).
• Uniprot ID: Q9C0C7