ALOX5 Antibody - C-terminal region (ARP63055_P050)

Catalog No: ARP63055_P050

Host: Rabbit
Target Name: ALOX5
Sample Type: HepG2 Whole Cell lysates
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ALOX5
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 86%; Dog: 79%; Guinea Pig: 92%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 86%
• Peptide Sequence: Synthetic peptide located within the following region: FGQLFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYY
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ALOX5 (ARP63055_P050) antibody is Catalog # AAP63055

Target Info

• Gene Symbol: ALOX5
• Gene Full Name: arachidonate 5-lipoxygenase
• Alias Symbols: 5-LO, 5LPG, LOG5, 5-LOX
• NCBI Gene Id: 240
• Protein Name: ALOX5 protein EMBL AAI43986.1
• Description of Target: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Uniprot ID: B7ZLS0
• Protein Accession #: NP_001243083
• Protein Size (# AA): 617
• Molecular Weight: 67kDa
• Protein Interactions: CEP57L1; NUTM1; SYCE1; CEP63; HHIPL2; COTL1; MAD1L1; REL; MEOX1; PIK3R1; DICER1; MAPKAPK2; LTC4S; ALOX5AP; APP; TGFBRAP1; GRB2; ACTB;