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Catalog No: OPCD01259
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OPCD01259
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Datasheets/ManualsPrintable datasheet for ALOX15B Recombinant Protein (OPCD01259)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Asp349-Val633
::Subcellular Location: Cytoplasm, cytosol. Cell membrane. Cytoskeleton. Nucleus. Membrane; Peripheral membrane prote
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolAlox15b
Gene Full Namearachidonate 15-lipoxygenase, type B
Alias Symbols15-lipoxygenase 2;15-LOX-2;15-LOX-B;arachidonate 15-lipoxygenase B;arachidonate 15-lipoxygenase type II;arachidonate 15-lipoxygenase, second type;linoleate 13-lipoxygenase 15-LOb;polyunsaturated fatty acid lipoxygenase ALOX15B.
NCBI Gene Id266604
Protein NameArachidonate 15-lipoxygenase B
Description of TargetNon-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
Uniprot IDQ8K4F2
Protein Accession #NP_695213.1
Nucleotide Accession #NM_153301.2
Protein Size (# AA)Asp349~Val633
Molecular Weight35.63kDa
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